Gold-installed biostable nanocomplexes for tumor-targeted siRNA delivery in vivo.

نویسندگان

  • Roun Heo
  • Hong Yeol Yoon
  • Hyewon Ko
  • Jung Min Shin
  • Jueun Jeon
  • Yee Soo Chae
  • Young Mo Kang
  • Dukjoon Kim
  • Doo Sung Lee
  • Jae Hyung Park
چکیده

The key issues, associated with nanocarriers for small interfering RNAs (siRNAs), are their poor stability and lack of tumor targetability in vivo. To address these issues, we developed gold-installed polyethyleneimine/siRNA complexes with a corona of PEGylated hyaluronic acid.

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عنوان ژورنال:
  • Chemical communications

دوره 51 93  شماره 

صفحات  -

تاریخ انتشار 2015